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Linda La Grange

Office of Research and Sponsored Projects
Office of Graduate Studies
New Mexico Highlands University

Phone: 505.454.3578
Fax: 505.454.3331
Email: lagrange_l@nmhu.edu

Linda_LaGrange_small

Faculty Information

Overview

Education

Undergraduate:
University of Alaska
BA Elementary Education/Music, 1972

Graduate:
New Mexico Highlands University
MS Experimental Psychology, 1987

Postgraduate:
University of Alberta
Ph.D. Experimental Psychology, 1989

 

Primary Research Interests

  • Hepatoprotective and fetoprotective properties of flavonoids in treatment of alcohol abuse
  • Identification of biological markers of excessive alcohol consumption
  • Biochemical correlates of personality traits/pathology
Professional Experience
1989-1993 Assistant Professor of Psychology, NMHU
1993-1997 Associate Professor of Psychology, NMHU
1997-present Professor of Psychology, NMHU
Summer 1996 On-Site research collaboration at Los Alamos National Laboratories
CST-1; FAST Project. Contact person, Dr. Chuck Wilkerson. Research consisted of development of HPLC methods to determine contaminants in synthesized inorganic substances.
1998-1999 Chair, Department of Behavioral Sciences
1999-2004 Associate Dean of Graduate Studies
2003-2004 Director of Institutional Research
2005-2007 Interim Associate Dean of the College of Arts and Sciences
2007-2008 Dean Graduate Studies & Research
2008-present Associate Vice President for Academic Affairs
Grants Recieved
1991-1993 NIH-NIAA RO3 $ 100,000/2 years
1994-1997 Herbs Etc., Santa Fe NM $ 6,000/year
1995-1997 Inverni della Beffa Milan, Italy $ 6,000/year
1997-1998 Inverni della Beffa, Milan, Italy $ 9,000/year
1998-1999 Inverni della Beffa, Milan, Italy $ 12,000/year
1999-2000 Inverni della Beffa, Milan, Italy $ 12,000/year
2000-2003 NIH/Bridges PD $ 540,000/3 years
1999-2001 NIH-NIAA R21 $ 176,000/2 years
2004-2005 Council of Graduate Schools $ 4,000/1 year
1999-2004 WAESO $ 7,760/year
Professional Service
NIH P20 Review Panel EXPORT Summer 2002; 2003
NIH Loan Repayment Program for Health Disparities Research Review Panel Spring 2004; 2009
NIH R24 Review Panel EXPORT Summer 2004; 2006
NIH T37 MHIRT International Research Training Program Spring 2005; Fall 2008
NIH LRP Special Emphasis Panel Spring 2006; 2007
NIH BRIC Summer 2010
New Mexico Council of Graduate Deans (Chair 2007-2008) 1999-2004; 2007-Present
Western Association of Graduate Schools Secretary-Treasurer 2009 -2012
New Mexico Alliance for Graduate Education and the Professoriate (AGEP) 2000-2005
NMHU NCA Committee 1998-Present
NMHU Strategic Planning Committee– Core Group 2003-Present
New Mexico Performance Effectiveness Planning Committee 2002-2004
New Mexico Mental Health Initiatives Panel 2003-2006
Expert Witness for Criminal Drug/Alcohol Cases 2005-Present
Judge Chavez Metro 1/15/09; 2008; 09/08/09 ABQ, NM (3)
Judge Jaramillo Metro Court; 04/23/10, 05/11/10
(partition coefficient; IR 8000)
ABQ, NM (4)
Judge Candelaria District Court ABQ, NM (1)
Judge Valdez Metro 12/04/08; 2007 ABQ, NM (2)
Judge Ramczyk Metro Court ABQ, NM (2)
Judge Engal Metro Court ABQ, NM (1)
Judge Magistrate 09/04/08 Santa Fe, NM (1)
Judge Reynolds District Court Estancia, NM (1)
Judge Rogers Metro 2007 ABQ, NM (3)
Metro 10/21/08
Metro 09/15/10
(Experimental Psychology, Psychopharmacology)
Judge Romero Magistrate (08/28/08) Las Vegas, NM (1)
Judge DeMerssman Metro (12/05/08) ABQ, NM (1)
Judge Altweiss Metro 01/12/09; 01/27/11 ABQ, NM (2)
Judge Dominguez Metro 02/06/09; 04/15/10 ABQ, NM (2)
The Hague ITCY 03/17/09 Netherlands (1)
Judge Clinton Metro 06/09/09 ABQ, NM (1)
Judge Campbell District 2009 expert report ABQ, NM (1)
Judge Fitzwater Metro Court ABQ, NM (3)
Metro Court 08/11/10
(Psychopharmacology; Physiological Psychology; Effects of GERD on IR 8000)
Metro Court 03/05/12
Psychopharmacology; Physiological Psychology)
Judge Wong Alberta, CA Provincial Court 06/23/10
(Research Methodology; Action of EtOH in Rodent Model)
Edmonton, AB (1)
Judge Zamora Metro Court (09/10)
(Human Metabolism of Alcohol)
ABQ, NM (2)
Metro Court (04/07/11)
IR 8000; SFST Methodology; Psychopharmacology)
Judge Benavidez Metro Court 10/20/10
(Psychopharmacology; IR 8000)
ABQ, NM (1)
Judge Nakamura Metro Court (01/13/11)
(Psychopharmacology, Breath Testing)
ABQ, NM (1)
Judge Walton Metro Court (06/29/11; 01/05/12)
SFSTs; Psychopharmcology; Physiological Psychology
ABQ, NM (2)
Judge Segura Santa Fe Magistrate Court (11/14/11)
(Psychopharmacology, Breath Testing, SFSTs)
SF, NM (1)
Judge Vigil Santa Fe District Court (05/09/12)
(Psychopharmacology; Extrapolation Back)
SF, NM (2)
Santa Fe District Court (09/19/12)
(Alcohol-induced Blackouts; Detection of Excessive Alcohol Consumption)
Judge Davis Sandoval District Court (08/10/12)
Psychopharmacology; SFST Methodology
RR, NM (1)
Mediator for Albuquerque Metro Court 2005-2007
Reviewer for the journal Personality and Individual Differences 1999 – Present
Reviewer for the journal Cellular and Molecular Biology Letters 2005
Reviewer for the journal Neuroscience Letters 2003
Reviewer for the journal Alcoholism: Clinical and Experimental Research 1993-1996
Reviewer for the Journal of Medicinal Plant Research 2012

 

Professional Societies
Research Society on Alcoholism
Society for Individual Differences
American Association of University Professors (AAUP)
New Mexico State Treasurer 1999-2000
Honor Societies
Phi Kappa Phi
Sigma Xi

 

Publications

Abstracts

Schreiber, H., Ortiz, M., Marquez, W., Garcia, M., Gonzalez, M., Maez, C., Klein, R., Bibb, M., & Calhoon, L. (1987). Early preweaning maternal behavior influences the sensitization of amphetamine-induced stereotypy following haloperidol administration in the adult offspring. Abstracts of Society of Neuroscience, 13, 221.

Calhoon, L. (1991). Space, time, and attention: Processing of stimuli delivered to the hands. Journal of Rehabilitation Research and Development, 28, 68.

 

Presented Papers

Calhoon (La Grange), L., Ortiz, M., Marquez, W., Garcia, M., Gonzalez, M., Maez, C., Klein, R., Bibb, M., & Schreiber, H. (1987). Early preweaning nestcage disturbance influences adult dopaminergic function through alterations in maternal behavior. International Society for Developmental Psychobiology, New Orleans, LA.

Calhoon (La Grange), L. (1988). Time, space, laterality and strategy in tactual processing. Joseph R. Royce Research Conference, Edmonton, AB, Canada

Calhoon (La Grange), L. & Lechelt, E. (1989). Laterality in tactile temporal processing. Western Canada Psychological Association, Alberta, Canada

La Grange, L., Anton, R., Crow, H., & Garcia, S. (1993). Carbohydrate-deficient transferrin: values for Southwestern U.S. Hispanic college students. Research Society on Alcoholism, San Antonio, TX

La Grange, L., Anton, R., Garcia, S., & Herrbold, C. (1994). Oral contrceptives and levels of carbohydrate-deficient transferrin (CDT) in a young female population. Research Society on Alcoholism, Maui, Hawaii.

Wang, M., La Grange, L., Reyes, E., & Tao, J. (1995). Silibum marianum extract: A hepatoprotective agent as measured by ethanol-induced enzyme activity in rats. Research Society on Alcoholism, Steamboat Springs, CO.

Yeastedt, J., La Grange, L., & Anton, R. (1995). Detecting relapse in female alcoholics using CDT levels and GGTP activity. Research Society on Alcoholism, Steamboat Springs, CO.

Yeastedt, J., & La Grange, L. (1995). Serum transaminases as biochemical markers of relapse in female alcoholics. American Psychological Association, New York, NY.

Matykiewicz, L., La Grange, L., Vance, P., & Wang, M. (1996). Biological correlates of aggression-hostility: Adjudicated males vs. control males. Rocky Mountain Psychological Association. Park City, UT.

Edwards, J., Wang, M., Pecore, N., & La Grange, L. (1998). The LD50 of kavalactones extracted from Piper methysticum in rats. Experimental Biology ’98. San Francisco, CA.

Reid, C., Edwards, J., Wang, M., Manybeads, Y., Mike, L., Martinez, N., & La Grange, L. (1998). Fetal rat exposure to EtOH: Protective effects of silymarin on learning and memory. Experimental Biology ’98. San Francisco, CA.

La Grange, L., Manybeads, Y., Mike, L., Martinez, N., Korte, H., Baca, E., Reid, C., & Wang, M. (1998). Fetoprotective effects in rats of silymarin against in utero exposure to ethanol. Experimental Biology ’98. San Francisco, CA.

J. Edwards, R, Madrid, C. Ortiz, S. Burge, M. Wang, J. Niemi, H. Soos, & L. La Grange (1998). Prenatal exposure to ethanol in rats: Protective effects of the bioflavonoid, silymarin. The American College of Toxicology ’98, Orlando FA.

J. Edwards, R. Madrid, C. Ortiz, S. Burge, M. Wang, J Niemi, H. Soos, & L. La Grange (1998). Chronic use of kava: Does it affect rat performance during active avoidance testing? The American College of Toxicology ’98, Orlando FA.

Z. Ding, J. Edwards, & L. La Grange (2000). Protective effect of silymarin and silibinin on ethanol-induced cell injuries in the human G2 cell line. International Behavioral Neuroscience Society, Denver, CO

G. Benally, A. Charley, P. James, L. Gonzales, J. Edwards, & L. La Grange (2000). Does the chronic administration of kava enhance cognitive functioning in rats during radial arm maze testing? International Behavioral Neuroscience Society, Denver CO.

A. Busby, J. Edwards, M. Wang, J. King, & L. La Grange (2000). Prevention of ethanol-induced social learning and visio-spatial deficits by Siliphosâ in a rat model of fetal alcohol syndrome. International Behavioral Neuroscience Society, Denver, CO.

Z.Y. Ding, H., H. Sonchar, B. Zhang, J. Edwards, & L. La Grange (2000). The effect of silybin on ethanol-induced cytotoxicity in Hep G2 cells. The American College of Toxicology ’00, San Diego CA.

Z. Ding, E. Klein, E., B. Zhang, J. Edwards, M. Houston, L. La Grange (2001). An improved method for assays of oxidative stress in tissues using an automated microplate reader. AAAS 2001, San Fransisco, CA.

N.M. Moreland, R.S. Montoya, & L. La Grange (2001). Fetal alcohol syndrome and laterality: The fetoprotective effects of silymarin. Neuroscience 2001. San Diego, CA.

Valdez, J., La Grange, L., & Pilotti, M. (2011). Alcohol and Triggered Displaced Aggression: Effects on Hispanic Males. American Psychological Association, Washington, DC.

Broderick, T., Pilotti, M., La Grange, L., Bochenek, J., Lucero, L., & Martinez, E. (2012). Forms of retrieval practice for learning in introductory psychology. Western Psychological Society.

Broderick, T., Pilotti, M., La Grange, L., Bochenek, J., Lucero, L., & Martinez, E. (2012). The effect of conceptual integration during practice on test performance. Rocky Mountain Psychological Society.

Broderick, T. O., Pilotti, M., Martinez, E., Caballero, S., & LaGrange, L. (2012). The effect of concentrated practice on reading skills. Poster presented at the 92nd Annual Convention of the Western Psychological Association.

Broderick, T. O., Pilotti, M., LaGrange, L., Bochenek, J. L., Lucero, L., & Martinez, E. (2012). Forms of retrieval practice for learning in introductory psychology. Poster presented at the 92nd Annual Convention of the Western Psychological Association.

Symposia

Underlying mechanisms of the fetoprotective activity of silymarin. Presented by: A. Busby, J. Edwards, M. Huston, & L. La Grange. Neurochemistry Winter Conference 2000, Sölden, Austria.

Publications (Refereed Journals)

Calhoon (La Grange), L., (1988). Explorations into the biochemistry of sensations seeking. Personality and Individual Differences, 9, 941-949.

Calhoon (La Grange), L. (1991). Sensation seeking, exercise, and dopamine beta hydroxylase. Personality annd Individual Differences, 12, 903-907.

Calhoon-La Grange, L., Jones, T., Reyes, E., & Ott, S. (1993). Monoamine oxidase levels in females: Relationships to sensation seeking, alcohol use, physical fitness, and menstrual cycle. Personality and Individual Differences, 12, 439-446.

La Grange, L., Anton, R., Crow, H., & Garcia, S. (1994). Correlates of GGTP and CDT with self-reported levels of alcohol consumption among college students. Alcoholism: Clinical and Experimental Research, 18, 653-656.

La Grange, L., Jones, T., Erb, L., & Reyes, E. (1995). Biochemical correlates of alcohol use in a student population. Addictive Behaviors, 20, 93-103.

La Grange, L., Anton, R., Garcia, S., & Herrbold, C. (1995). Oral contraceptives and CDT values in a female population. Alcoholism: Clinical and Experimental Research, 19, 100-103.

Wang, M., La Grange, L., Reyes, E., & Tao, J. (1996). Hepatoprotective properties of milk thistle extract as measured by ethanol-induced enzyme activity in rat model. Fitoterapia, 67, 166-171.

Matykiewicz, L., La Grange, L., Vance, P., Wang, M., & Reyes, E. (1997). Adjudicated adolescent males: Measures of urinary 5-hydroxyindoleacetic acid and reactive hypoglycemia. Personality and Individual Differences, 33, 327-332.

Matykiewicz, L., La Grange, L., Reyes, E., Vance, P., & Wang, M. (1997). Adolescent Males, Impulsive/Aggressive behavior, and Alcohol Abuse: Biological Correlates. Journal of Child and Adolescent Substance Abuse, 6, 27-37.

Yeastedt, J., La Grange, L. & Anton, R. (1998). Female alcoholic outpatients and female college students: A correlational study of self-reported alcohol consumption and carbohydrate-deficient transferrin levels. Journal of Studies on Alcohol, 59, 555-559.

Talbot, R., & La Grange, L. (1999). The effects of salty and nonsalty food on peak breath alcohol concentration and divided attention task performance in females. Substance Abuse

La Grange, L., Wang, M., Watkins, R., Ortiz, D., Sanchez, M., Konst, J., Lee, C., & Reyes, E. (1999). Fetal protective effects of the flavonoid mixture, silymarin, on fetal rat brain and liver. Journal of Ethnopharmacology, 65, 53-61.

Reid, C., Edwards, J., Wang, M., Manybeads, Y., Mike, L., Martinez, N., La Grange, L., & Reyes, E. (1999). Prevention of ethanol-induced social learning deficits in rats. Planta Medica, 65, 421-424.

Edwards, J., La Grange, L., Wang, M., & Reyes, E. (2000). Fetoprotectivity of the flavanolignan compound siliphos against ethanol-induced toxicity. Phytotherapy Research, 14, 517-521.

Busby, A., La Grange, L., & Edwards, J. (2002). The Use of a Silymarin/Phospholipid Compound as a Fetoprotectant from Ethanol-Induced Behavioral Deficits. Journal of Herbal Pharmacotherapy, 2, 39-47.

Moreland, N., La Grange, L., & Montoya, R. (2002). Impact of In Utero Exposure to EtOH on Corpus Callosum Development and Paw Preferences in Rats: Protective Effects of Silymarin. BMC Complementary and Alternative Medicine, 2, 10.

La Grange, L., Ding, Z., Houston, M., & Klein, E. (2003). Normalizing Effects of Bioflavonoids on EtOH-Induced Indices of Lipid peroxidation in Rat Neonates and Dams. Pharmaceutical Biology. 41, 188-193.

Neese, S., La Grange, L., Trujillo, E., & Romero, D. (2004). The effects of ethanol and silymarin treatment during gestation on spatial working memory. BMC Complementary and Alternative Medicine, 4, 10.

Ortiz, J. & La Grange, L. (2006). The efficacy of relaxation techniques in increasing sport performance in women golfers. The Sport Journal, 9, 1.

Richardson, D.W., Cave, S.B., & La Grange, L. (2008). Prediction of police officer performance among New Mexico State Police as assessed by the Personality Assessment Inventory. Journal for Police and Criminal Psychology.

La Grange, L., Hojnowsky, N., & Nesterov, S. (2007). Personality correlates of alcohol consumption and aggression in an Hispanic college population. Hispanic Journal of Behavioral Sciences.

Pilotti, M., Martinez, E., Broderick, T., Caballero, S, & LaGrange, L. (2012). Reading acceleration program: The effect of concentrated practice on reading skills. Journal of Hispanic Higher Education, XX(X), 1-14.

Publications (Lay Journals)

Calhoon, L. (1991). Need tests for women drinkers. The U.S. Journal, 8.

La Grange, L. (1992) Beta-carbolines and alcoholism: associations and implications. Science Matters, 3, 17.

La Grange, L. (1996). A natural tonic for liver disease? Science Matters, 2, 18.

La Grange, L. (2005). Oshà, Yerba del a Gente, The New Mexico Native Plant Society Newsletter, September.

La Grange, L. (2006). Inmortal: A favorite northern New Mexico Remedy. The New Mexico Native Plant Society Newsletter, April.

La Grange, L. (2007). Yerba Mansa: The gentle herb. The New Mexico Native Plant Society Newsletter.

 

Book Chapter

La Grange, L. (1994). Gender differences in biological markers of alcohol use. In R. Watson (Ed.) Addictive Behaviors in Women, pp. 125-158, Humana Press: NJ

 

Presentations

Appearances

Courses

Courses Taught Relevant to Drug Effects

 

1. Psych 612 Psychopharmacology (taught 22 times)

Course description:Students are to be provided information and instruction in the following concepts and applications:

  • Basic pharmacological principles including absorption, distribution, inactivation, and elimination
  • Cellular mechanisms involved in drug action
  • Knowledge of the major neurotransmitter and neuroendocrine systems
  • Therapeutic uses of psychoactive drugs

Required Text: Molecular Neuropharmacology: A Foundation for Clinical Neuroscience by Nestler, Hyman, & Malenka

2. Psych 4/508 Drugs and Behavior (taught 17 times)

Course description: Provide the student with information regarding the following types of drugs:

  • Prescription medications
  • Over-the-counter drugs
  • Licit and illicit recreational drugs
  • Familiarize the student with the following:
    • Physiological effects of drugs
      • Neural mechanisms
        • neuroanatomy
        • receptor types
        • neurotransmitter systems
    • Psychological effects of drugs
    • Social effects of drugs

Required textbook: Drugs Behavior & Modern Society by C. Levinthal

3. Psych 4/510 Physiological Psychology (taught 17 times)

Course description: Students will be introduced to the basic structures of the brain and taught the associations between structure and behavioral function. As well, students will be exposed to the fundamental, neurological, behavioral, and developmental aspects of neuropsychology. The course will also cover the mechanisms underlying the sensory and motors systems. The lab portion of the course will be devoted to a more concentrated study of neuroanatomy

Required textbook: Physiological Psychology by N. Carlson

 

Courses Taught Relevant to the SFST

 

1. Psych 301/302 Research Methods and Analysis (taught 4 times)

Course description: To introduce the students to the terminology, logic, and goals of statistics; teach the students to determine simple, relative, and cumulative frequency tables; Teach the students the relevance of the concept of statistical variability; to introduce the students to the use of z-scores and their relationship to the concept of central tendency; teach the students how to compute and interpret correlation coefficients and linear regression; introduce the students to the concept of probability and how it impacts the use of inferential statistics; introduce the concept of hypothesis testing; teach the students to analyze data using t-tests and ANOVAs; and review the concept of non-parametric testing.

Required Textbook: Basic Statistics for the Behavioral Sciences by G.W. Heiman

2. Psych 602 Behavioral Research Methods (taught 6 times)

Course description: This course is designed for graduate level psychology students. There are several areas of concentration:

  • Survey design
  • Experimental research design
  • Application of appropriate statistical analyses to each type of research design
  • Interpretation of experimental results as reported in journals and other scholarly sources
  • Critique of the research designs reported in the literature

 

Laboratory Techniques Training

 

Summer 1988

Dr. Robert Amai (mentor), New Mexico Highlands University

  • HPLC
  • Spectrophotometry

Summer 1990-1993

Dr. Edward Reyes (mentor), UNMHSC School of Pharmacy

  • HPLC
  • Spectrophotometry
  • Liquid Scintillation Spectrometer
  • RIA/gamma counter

Summer (1 week) 1991

Dr. Ray Anton (mentor), University of South Carolina Medical School

  • RIA/gamma counter

 

Summer 1996

Dr. Chuck Wilkerson (mentor), Los Alamos National Laboratory

 

1990-current

I have a fully equipped biochemistry laboratory in Hewett Hall, New Mexico Highlands University. It has been in active use for 18 years, serving my research needs as well as those of other NMHU faculty members. In the lab is an Intoxilyzer 5000, which I am using for my current research of alcohol and aggression.