Arcadius V. Krivoshein, Ph.D.
Assistant Professor of Analytical Chemistry
Office: HSCI 234
1990-1995 B.S. + M.S. studies (major: Biology, minor: Education in Biology and Chemistry), Kuban State University, Krasnodar, Russia.
1995-1998 Ph.D. studies in Bioorganic Chemistry, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences. Thesis: “Physico-chemical studies of Torpedo californica acetylcholine receptor functional domains” (advisors: Drs Yuri N. Utkin and Alexander S. Arseniev).
1999-2000 Postdoctoral training in protein chemistry, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ (advisor: Dr. Ronald J. Lukas).
2000-2003 Postdoctoral training in chemical kinetics, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY (advisor: Dr. George P. Hess).
Courses Taught at NMHU
Advanced Analytical Chemistry, Integrated Chemistry Laboratory
Biochemistry 1 and 2, Biochemistry Lab
Chemistry Colloquium, Senior Chemistry Applications
- Structural chemistry of antiepileptic drugs
- Method development in chromatography and mass spectrometry
- Metabolomics of Alzheimer’s disease
Selected Publications (in the last 3 years only)
- Krivoshein, A. V., and Hu, Z. (2021) Non-ideal behavior of void volume markers in polar organic mode chiral HPLC on Chiralcel and Chiralpak columns (manuscript in preparation for submission to Journal of Liquid Chromatography and Related Techniques)
- Krivoshein, A. V. (2020) α-Substituted lactams and acetamides: Ion channel modulators that show promise in treating drug-resistant epilepsy. Cent. Nerv. Syst. Agents Med. Chem. 20, 79-87.
- Dubrovskiy, A. V., and Krivoshein, A. V. (2020) Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures. US Patent Application 20200360342.
- Timofeeva, T. V., Sena, V., Averkiev, B. B., Bejagam, S. N., Usman, M., Krivoshein, A. V. (2019) Unusual polymorphs of rac-3-phenylpyrrolidine-2,5-dione with Z’=1, 2, and 3. CrystEngComm 21, 316-326.
- Rigin, S., Armijo, B., Krivoshein, A. V., Fonari, M. & Timofeeva, T. (2019) Crystal structure and Hirshfeld surface analysis of new polymorph of racemic 2-phenylbutyramide. Acta Crystallogr. E75, 826-829.
- Krivoshein, A. V., Lindeman, S. V., Bentum, S., Averkiev, B. B., Sena, V., and Timofeeva, T. V. (2018) Molecular arrangements in crystals of racemic and enantiopure forms of N-carbamoyl-2-phenylbutyramide and 2-phenylbutyramide: differences and similarities. Z. Kristallogr. Cryst. Mater. 233, 781-793.
- Krivoshein, A. V., and Ermolenkov, V. (2018) The persistent ‘memory effect’ of triethylamine in atmospheric pressure ionization sources can be effectively controlled by decontamination with a iPrOH/AcOH mixture. Rapid Commun. Mass Spectrom. 32, 824-826.
The full list of my published work can be accessed at My Bibliography (NCBI)
David M. Sammeth, Ph.D.
Professor of Physical Chemistry
Office: HSCI 232
1992-1993 Postdoctoral Fellow, George Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA
1986-1992 PhD, Montana State University, Bozeman, MT. with Patrik Callis
Thesis – Polarized Two-Photon Fluorescence Excitation Studies of Jet-Cooled Indoles.
1981-1985 B.S Chemistry, minors: mathematics and literature
University of Puget Sound, Tacoma, WA
Chemistry for Non-Majors
Senior Chemistry Applications
Thermal luminescence and optically stimulated luminescence (TL/OSL) dating of archaeological and geological events ranging from years to several hundred thousand years. In particular, the understanding of the characteristics of electron traps created within quartz and feldspar.
- Lail, Warren, Sammeth, David, Mahan, Shannon and Jason Nevins. A Non-Destructive Method for Dating Native Human Remains. Advances in Archaeological Practice: A Journal of the Society for American Archaeology. (2013) 1(2), 91–104.B
- Victor Khrustaleva, Shravana Nayanib, Evgeniya S. Leonovab, Lada N. Puntusc, David M. Sammeth, Irina L. Odinetsa, and Tatiana V. Timofeeva. Structure-property relationships for N-phosphoryl substituted E,E-3,5-bis(arylidene)piperid-4-ones. J. Molec. Struct (2013) 1043 68-74
- W. Short, T.L.Kinnibrugh, D.M. Sammeth, and T.V. Timofeeva. Spectroscopic, cyto-, and photo-toxicity studies of substituted piperidones: potential sensitizers for two-photon photodynamic therapy. Proc. of SPIE (2009) Vol. 7164, 716411-9
- B. Masthay, D.M. Sammeth, M.C. Helvenston, C.B. Buckman, W. Li, M.J. Cde Baca, and J.T. Kofron. The Laser-Induced Blue State of Bacteriorhodopsin: Mechanistic and Color Regulatory Roles of Protein-Protein Interactions, Protein-Lipid Interactions, Metal Ions, and pH.J.Am. Chem. Soc. (2002) 124 3418-3430
- R. Fletcher, M. Rekow, D. Rogge, and D.M. Sammeth. Vaporization of Nonvolatile and Matrix Isolated Molecules Using a Novel Laser Vaporization Technique. Applied Spect. (1996) 50 19 (awarded the 1997 Meggars award for outstanding paper, Society for Applied Spectroscopy)
- Berger, Y. Wang, D.M. Sammeth, I. Itzkan, K. Kneipp and M.S. Feld. Aqueous Dissolved Gas Measurements Using Near-Infrared Raman Spectroscopy. Applied Spect. (1995) 49 1164-1169.
- M. Sammeth, L.H. Spangler, S. Siewart, and P.R. Callis. 1La Transitions of Jet-Cooled 3-methylindole. Chem. Phys. Lett. (1992) 193 532-538.
- M. Sammeth, P.R. Callis, S.S. Siewart, and L.H. Spangler. Methyl Rotor Effects in 3- and 5-Methyl Indole. J. Phys. Chem. (1992) 96 5771-5778.
- M. Sammeth, S. Yan, L.H. Spangler, and P.R. Callis. Two-Photon Fluorescence Excitation Spectra of Indole in Vapor and Jet: 1La States. J. Phys. Chem. (1990) 94 7340-7342.
2015-2017: TL/OSL Dating: Lattice Structure, Dating Accuracy, and Temporal Minima in Synthetic and Natural Models
Army Research Office, Basic and Applied Scientific Research. $369,893
Naveen Singh, Ph.D.
Asst. Professor of Biochemistry
Office: HSCI 233
2017-2020 Faculty/Postdoctoral Researcher, Advisor: Dr. David A Boothman, Dept. of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN
2016-2017 Postdoctoral Researcher, Advisor: Dr. David A Boothman, Pharmacology and Radiation Oncology, UT Southwestern Medical Center, Dallas, TX
2015-2016 Postdoctoral Researcher, Advisor: Dr. Narayan Avadhani, Dept. of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA
2010-2015 Ph.D., Advisor: Dr. Aaron M. Rowland, Dept. of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM
Thesis – Hypoxic regulation of Cytochrome P450 2S1 and its role in the metabolism of anti-cancer prodrug AQ4N.
Environmental Toxicology, Cytochrome P450s, DNA repair pathways, Phase I/II drug metabolizing enzymes and ways to enhance synthetic lethality of anti-cancer drugs.
“Following anticancer drug activity in cell lysates with DNA devices,” Kahanda D, Singh N, Boothman DA, Slinker JD. Provisional Patent, Filed Apr 2019.
- Singh, N.; Pay, S.L.; Bhandare, S.B.; Arimpur, U.; Motea, E.A. Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy. Cancers 2020, 12, 972.
- Shukla K, Singh N, Lewis JE, et al. MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer. Front Oncol. 2020;10:536377. Published 2020 Nov 11.doi:10.3389/fonc.2020.536377
- Patidar PL, Viera T, Morales JC, Singh N, Motea EA, Khandelwal M, Fattah FJ. XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. Sci Rep. 2020 Aug 28;10(1):14253. doi: 10.1038/s41598-020-71203-7. PMID: 32859985; PMCID:PMC7455564.
- Starcher CL, Pay SL, Singh N, Yeh I-J, Bhandare SB, Su X, Huang X, Bey EA, Motea EA and Boothman DA (2020) Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer. Front. Oncol. 10:1575. doi: 10.3389/fonc.2020.01575
- Edward M, Xiumei H, Naveen Singh, Jessica Kilgore, Noelle Williams, Xian-Jin Xie, David Gerber, Muhammad Beg, Erik Bey, and David Boothman. NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers. Clin Cancer Res.2019;25:2601–2609.
- Naveen Singh, Joshua E. Lewis, Reetta J. Holmila, Baran D. Sumer, Noelle S. Williams, Cristina M. Furdui, Melissa L. Kemp, David A. Boothman. Targeting NAD+ metabolismto enhance radiation therapy responses. (Seminars in Radiation Oncology, Apr 2018)
- Kahanda D, Singh N, Boothman DA, Slinker JD. Following anticancer drug activity in cell lysates with DNA devices. Biosens Bioelectron. 2018 Jul 30;119:1-9.
- Chen X, Mims J, Huang X, Singh N, Motea EA, Planchon SM, Beg M, Tsang AW, Porosnicu M, Kemp ML, Boothman DA, Furdui C. Modulators of Redox Metabolism in Head and Neck Cancer. Antioxid Redox Signal. 2017
- Lyday RW, Etters MA, Kim C, Magana F, Pontipiedra GM, Singh N and Kadavakollu S*, PDE5 Inhibitors Offer Novel Mechanisms in Combination and Solo Cancer Therapy, Current Cancer Therapy Reviews, 2017.
- Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME. The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism. J Biol Chem. 2017.
- Anandasadagopan SK, Singh N, Haider Raza, et al., “β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment,” Oxidative Medicine and Cellular Longevity, 2017.
- Singh N, White, S. R., Kalagara, S. & Kadavakollu, S. Inhibition of CYP2S1 mediated metabolism of anticancer prodrug AQ4N by liarozole. J. Appl. Pharm. Sci. 7, 1–7 (2017).
- Chandran A, Kadavakollu S*, White S, Andra KK, Singh N and Vemula R. Translational Fidelity Mediated Regulation of ER-Stress by Dph3. J. Biomed. Sci. 5, 1–5 (2016).
Naveen Singh, Edward A. Motea, Xiumei Huang, Colton L. Starcher, Jayne Silver, I-Ju Yeh, S. Louise Pay, Xiaolin Su, Kristen A. Russ, David A. Boothman and Erik A. Bey (February 13th 2020). NQO1-Bioactivatable Therapeutics as Radiosensitizers for Cancer Treatment [Online First], IntechOpen, DOI: 10.5772/intechopen.90205.
2020-2021: Faculty Research Committee, NMHU – $5000
Alan K. Thomas
Visiting Assistant Professor of Physical Chemistry
Office: HSC Room #237
Ph.D. in Chemistry, University of New Mexico, July 2016
B.A. in Chemistry with Mathematics minor, University of New Mexico, May 2009
Courses taught at NHMU
- Solar Energy Materials (650)
- Physical Chemistry I & II (3710/3720)
- General Chemistry I & II (2120/2120)
- Inorganic Chemistry (4610/5610)
- Physical Chemistry Laboratory (3454)
- Advanced Synthesis and Instrumental Analysis Laboratory (4190/5190)
- Chemistry for the Non-Scientist (1100), and a selection of associated Laboratory sessions
- Chemistry Colloquium (6910)
- Chemistry Research Seminar (2450/ 4450/ 5550)
Three-dimensional Polymers for Organic Photovoltaics Applications
Cumulus and Cumulonimbus Cloud Formation via Capacitative Discharge
Limit Testing Free Space Polarizability
Molecular Structure and Exciton Dynamics in Organic Conjugated Polymers
Selected Publications (Current Citation Count from Google Scholar: 369. h-index: 10)
Thomas, A.K., Johnson, R., Stein, B.W., Kirk M.L., Guo, H., Grey J.K. (2017) “Charge Transfer Doping Induced Conformational Ordering of a Non-Crystalline Conjugated Polymer” J. Phys. Chem. C, 121 (42), pp 23817–23826
Thomas, A.K., Kouhestani, C., Grey, J.K. (2016) “Ionizing radiation exposure reveals instability of purified domains in polymer/fullerene solar cells.” Solar Energy Materials and Solar Cells 160: 85-93
Thomas, A.K., Brown, H.A., Datko, B., Garcia-Galvez, J.A., Grey, J.K. (2016) “Interchain charge transfer states mediate triplet formation in purified conjugated polymer aggregates.” Journal of Physical Chemistry C 120 (40): 23230-23238
Thomas, A.K., Garcia Garcia-Galvez, J.A., Ulibarri-Sanchez, J., Gao, J. Grey, J.K. (2014) “High intrachain order promotes triplet formation from recombination of long-lived polarons in poly(3-hexylthiophene) j-aggregate nanofibers.” ACS Nano 8 (10): 10559-10568
Professional and Academic Affiliations
American Chemical Society (ACS) [member] 2012 — present
American Association for the Advancement of Science (AAAS) [member] 2014 — present.
Materials Research Society [member] 2015 — present